The Art of Surgical Science
UpSurgeOn is a team of Surgeons from various disciplines working closely with a team of Developers, Digital Artists, Modelers, Engineers, and other Creative Thinkers. Our goal is to enhance the way surgical knowledge is transmitted and practiced. To do this we invented the most advanced simulation Technology ever.
Our Mission
Making surgical excellence accessible at a global level
Discover our purpose to change the world
Timeline UpSurgeOn History
INCUBATION
2014
First Steps
In 2014, Dr. Federico Nicolosi and Dr. Giannantonio Spena, two neurosurgeons, marked a pivotal moment with the inaugural use of in-house 3D virtual models and 3D printed models for preoperative planning.
.
2015
First Scientific
Publication
Dr. Nicolosi and Dr. Spena marked a significant milestone in 2015 with the publication of their inaugural Scientific Paper, introducing a Novel Method for utilizing 3D models and physical reconstructions in clinical cases.
PROOF OF CONCEPT
2017
Foundation
UpSurgeOn S.R.L. was established in 2017 as a MedTech Company headquartered in Milan. At its foundation, the company comprised a team of 5 members.
INCUBATION
2019
The First Grant
In 2019, UpSurgeOn secured the Horizon 2020 Grant, awarded by the European Innovation Council (EIC) for technological innovation. This marked a transformative moment as the UpSurgeOn team expanded to 12 members.
INCUBATION
2019
The First Patent
UpSurgeOn files the initial patent on the integration of 3D and physical reality.
INCUBATION
2020
Horizon Project Development
During 2020-2021, UpSurgeOn pioneered the development of the first 6 Neurosurgical Procedures, devising both digital and physical development methodologies that serve as the foundation for contemporary development practices. By the end of 2021, UpSurgeOn had grown to a team of 20 members.
INCUBATION
2021
Market Entry
UpSurgeOn launched its products into the market through the UpSurgeOn online store.
INCUBATION
2022
Round A
A capital increase took place in 2022, facilitated by an Industrial Investor, Guala Dispensing Group, specializing in global plastic industrial production with 15 factories worldwide.
INCUBATION
2022
Patents
UpSurgeOn successfully secures the filing of 9 international patents.
EXPANSION
2023
Team and Company Expansion
In 2023, UpSurgeOn expanded its presence by establishing a legal entity in the United States, transforming the company with a workforce of 38 members.
.
2023
Diversification into Other Disciplines
After making inroads in neurosurgery and ENT, UpSurgeOn expanded its scope into spinal surgery and plastic surgery.
EXPANSION
2023
Global Commercial Expansion
UpSurgeOn products reach 99 countries. UpSurgeOn Technologies are utilized by more than 300 Scientific Institutions and over 200 MedTech companies.
EXPANSION
2023
Second Grant
UpSurgeOn achieved another significant milestone in 2023 by securing a grant for the research and development of the first avatar patients and artificial intelligence, provided by the Lombardy region.
EXPANSION
2025
Partnership with Inovus Medical
In 2025, UpSurgeOn announced a global strategic partnership with Inovus Medical
EXPANSION
2026
€5 Million Investment Round
In 2026, UpSurgeOn closed a €5 million equity round led by CDP Venture Capital, with Simest, Deep Ocean Capital, Azimut Libera Impresa and FBH. The funds accelerate global expansion, new surgical specialties and R&D, with technology now present in 110+ countries.
Countries
Scientific Institutions worldwide adopted our Technologies
MedTech companies worldwide are using our technologies for marketing and training
THE PROBLEM
Training in neurosurgery is a healthcare emergency.
Steep learning curves, expensive programs, no simulation-based certifications, limited access to cadaveric dissection.
More than 5 million of cases not-treated each year globally due to the absence of trained surgeons.
Million Extra surgeries needed/year
Of malpractice of claims to Neurosurgery only
Million Global Surgery mortality deaths/year
Vision
Reach a universal
framework for all surgeries
In this new era, we’re not just adopting Technology; we’re leading a revolution. Our commitment to excellence goes beyond surgeons’ proficiency, emphasizing the positive impact on patients’ lives. Simulation-based training embodies a vision at the nexus of science, culture, and humanity, envisioning a future where each surgery is a masterpiece of skill, compassion, and innovation.
Mental training
Hybrid Training
Manual Training
Values
Beyond surgery and back
to the essence of medicine



Bando Ricerca&Innova Regione Lombardia



Bando Ricerca&Innova Regione Lombardia

Fondo Europeo di Sviluppo Regionale 2021/2027 di Regione Lombardia PR FESR 2021-2027
Partnered by
Partnered with
Join UpSurgeOn Community
Read Privacy Policy and Cookie Policy